Bisphosphonates adverse-events network meta-analysis: event-specific results

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Hepatotoxicity

Network geometry summary

Proportion of potential comparisons with direct data: 0.31

Proportion of treatments compared to more than one other: 0.67

Median number of studies per direct comparison: 1 (interquartile range 1-1)

Proportion of direct comparisons informed by more than one study: 0.18

Meta analysis results

Estimates (and 95% credible intervals) of the odds ratio of each bisphosphonate treatment, versus observation only, under

• (green) the best-fitting network meta-analysis model (if feasible)

• (blue) an equivalent meta-analysis of direct comparisons of the same treatment versus an observation-only control, and

• (red) all study-specific direct comparisons odds ratios corresponding to direct comparisons of the treatment with a no-treatment control. Placebo controls (dotted lines) are distinguished from observation-only controls (solid lines).

The panels distinguish the treatment categories under the best-fitting network meta-analysis model.

Note:

• there is one red line for each active study arm in each study containing a placebo or observation-only control. Note that this excludes comparisons of one bisphosphonate against another, which contribute to the network-meta analysis pooled estimates along with the direct comparisons.

• the blue line (direct-data pooled estimate) is the weighted average of all solid red lines (study-specific comparisons against observation-only). If there is no blue line on a particular panel, there were no studies that directly compared that treatment against an observation-only control.

• the green line (network meta-analysis pooled estimate) will not necessarily appear to be the average of the red lines, since the network meta-analysis also includes indirect data from the bisphosphonate-bisphosponate comparisons that are not illustrated

• there is no green line if no network meta-analysis was feasible.

Comparison of different treatment groupings

Network meta-analysis models defined on different groupings of treatments are compared.

• The treatment groupings compared for this symptom are those for which there is a connected network of trials reporting that symptom.

• Lines indicated pooled estimates of the odds ratio for each treatment against observation only, under the network meta-analysis model on that treatment grouping.

• The statistical fit of the models on different treatment groupings is compared using the deviance information criterion (DIC). DIC are presented relative to the best-fitting model (DIC = 0), and higher DIC indicate worse fit.

For the event HEPATOTOXICITY, observation-only and placebo are considered separately.